反应详情

150 g (0.5 mol) of 81% pure sodium 2-chloro-5-nitrobenzenesulphinate are presented in 300 ml of water at pH 8-8.5 and 60° C. To this are added dropwise in the couse of about 8 hours 200 ml of propylene oxide while the pH of the reaction mixture is constantly maintained between 7.5 and 9.5 with 20% strength sulphuric acid. After cooling down, the solids are filtered off with suction and washed twice with 200 ml of water. Drying at 70° C. in vacuo gives 118 g of colourless 2-chloro-5-nitrophenyl 2-hydroxypropyl sulphone.

1. temperatureAfter cooling down
2. filtrationthe solids are filtered off with suction
3. washwashed twice with 200 ml of water
4. customDrying at 70° C. in vacuo