HCID 13827271, compound → HCID 13827272, compound

Participants

Reaction Conditions

Reaction Steps

Trans-6-[2-(4-Hydroxyphenyl)ethenyl]-1(2H)-phthalazinone (12.4 gm) (produced in Example 2) was dissolved in 415 ml DMF by warming to 45° C. The solution was cooled back to 20° C. and diluted with an additional 200 ml DMF. The slightly cloudy solution was clarified by filtration, and the clear solution was irradiated in a soft glass container with 254 nm ultraviolet light for about 24 hours. The resulting solution was added with stirring to 6 L. water and allowed to settle for about 2 hours. The supernatant fluid, was decanted and the solid residue was filtered and washed with water and dried. Wt=7.4 gm, >95% cis by HPLC. mp=210°-22-° C (d).

Provenance & Evidence