Potassium Iodide → 6-Iodophthalide

HRID 978653Notes

Reaction equation

N[C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][O:7][C:8]2=[O:9])=[CH:4][CH:3]=1.[I-:12].[K+]>>[I:12][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][O:7][C:8]2=[O:9])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 4875Potassium Iodide

HCID 936316-Aminophthalide

Product 1

HCID 71741666-IodophthalideYield 23%

Procedure

The 6-iodophthalide was prepared in 23% yield via diazotization of 6-aminophthalide and subsequent treatment of the diazonium salt with potassium iodide according to the method of Tassman (Rec. Trav. Chim. Pays-Bas, 46, 653).

Sources & evidence

ORD record: ord-c75b5944dc2340de8a4c84cf9421fe75
Source dataset: uspto-grants-1987_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04665181

Reaction notes

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