HCID 18624687, compound → Hexahydro-3-fluoro-4-[3-[(tetrahydro-2H-pyran-2-yl)oxy]-4-fluoro-1-octenyl]-2H-cyclopenta[b]furan-2-one

HRID 978707Notes

Reaction equation

HRID 978707 reaction equation
[F:1][CH:2]1[C:6](=[O:7])[O:5][CH:4]2[CH2:8][CH2:9][CH:10]([CH:11]=[CH:12][CH:13]([OH:20])[CH:14]([F:19])[CH2:15][CH2:16][CH2:17][CH3:18])[CH:3]12.[O:21]1[C:25](=O)[CH:24]=[C:23]2[CH:27]=[CH:28]C=C12>>[F:1][CH:2]1[C:6](=[O:7])[O:5][CH:4]2[CH2:8][CH2:9][CH:10]([CH:11]=[CH:12][CH:13]([O:20][CH:25]3[CH2:24][CH2:23][CH2:27][CH2:28][O:21]3)[CH:14]([F:19])[CH2:15][CH2:16][CH2:17][CH3:18])[CH:3]12

Participants

3

Reactant 2

HCID 18624687HCID 18624687, compoundHCID 77855330hexahydro-3-fluoro-4-(3-hydroxy-4-fluoro-1-octenyl]-2H-cyclopenta[b]furan-2-one

Product 1

HCID 77855170Hexahydro-3-fluoro-4-[3-[(tetrahydro-2H-pyran-2-yl)oxy]-4-fluoro-1-octenyl]-2H-cyclopenta[b]furan-2-one

Procedure

By the procedure of Example 5 [3aR-[3aα,4α(1E,3R*,4R*)6aα]]-hexahydro-3-fluoro-4-(3-hydroxy-4-fluoro-1-octenyl]-2H-cyclopenta[b]furan-2-one was converted to [3aR-[3aα,4α(1E,3R*,4R*)6aα]]-hexahydro-3-fluoro-4[3-(tetrahydro-2H-pyran-2-yl)oxy]-4-fluoro-1-octenyl]-2H-cyclopenta[b]furan-2-one.

Sources & evidence

ORD record
ord-22112425472749308f4fcd985e9c27ce
Source dataset
uspto-grants-1987_05
Patent number
US04665198

Reaction notes

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