Sodium borohydride → HCID 20203549, compound

Participants

Reaction Conditions

Reaction Steps

Sodium borohydride (19 g, 500 mmol) was added portionwise upon cooling to a solution 8,8-diethyl-6,7,8,9-tetrahydro-10-methylpyrido[1,2-a]indol-9-one (12.8 g, 50 mmol) in methanol (500 mL) at 25° C. The reaction mixture was heated at 40° C. for 18 hours. The solvent was removed in vacuo and the residue partitioned between 1% ammonium hydroxide (100 mL) and chloroform (120 mL). The separated organic layer was dried over MgSO4, filtered and evaporated to afford the desired alcohol 12 g, (93%) as a greenish oil.

Provenance & Evidence