Sodium borohydride → HCID 13749192, compound

Participants

Reaction Steps

To a solution of 2-bromo-10-methyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-one (5.56 g, 20 mmol, described in Example 17, Step 1), in methanol (350 mL) was added sodium borohydride (2.5 g) portionwise, upon cooling. The reaction mixture was stirred at room temperature for 1 hour, and evaporated. The residue was partitioned between water and methylene chloride, the organic layer separated, dried (MgSO4), filtered, and evaporated to obtain the title compound 3.4 g (61%), m.p. 120°-123° C.

Provenance & Evidence