3,4-Dimethoxyaniline → HCID 54200082, compound

HRID 978741Notes

Reaction equation

HRID 978741 reaction equation
[C:1]([C:4](CC(O)=S)=[S:5])(=[O:3])[NH2:2].[CH3:10][O:11][C:12]1[CH:13]=[C:14]([CH:16]=[CH:17][C:18]=1[O:19][CH3:20])[NH2:15]>C(O)C.O>[C:1]([C:4]([NH:15][C:14]1[CH:16]=[CH:17][C:18]([O:19][CH3:20])=[C:12]([O:11][CH3:10])[CH:13]=1)=[S:5])(=[O:3])[NH2:2]

Participants

5

Reactant 2

HCID 227703,4-DimethoxyanilineHCID 178514056HCID 178514056, compound

Product 1

HCID 54200082HCID 54200082, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

The solution of carbamoyl-thiocarbonyl thioacetic acid prepared above was added to a solution of 3,4-dimethoxy-aniline (20 g) in ethanol (100 ml) and water (100 ml). The mixture was allowed to stand in a sealed vessel for 2 hr. The ethanol was evaporated under reduced pressure until crystallisation occurred. The product was collected by filtration, washed with cold ethanol, and dried to give N-(carbamoyl-thiocarbonyl-)-3,4-dimethoxyaniline (14.13 g); m.p. 149°-151° C.

Workup

  1. customThe ethanol was evaporated under reduced pressure until crystallisation
  2. filtrationThe product was collected by filtration
  3. washwashed with cold ethanol
  4. customdried

Sources & evidence

ORD record
ord-e8341cbb257d401ca787564d5ef000ae
Source dataset
uspto-grants-1987_05
Patent number
US04665206

Reaction notes

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