2',4'-Dihydroxy-3'-propylacetophenone → methyl 3-[7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]-3,4-dihydro-2-methyl-8-propyl-2H-1-benzopyran-2-yl]propanoate
Reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:22]=[CH:21][C:9]2[CH2:10][CH2:11][C:12]([CH2:15][CH2:16][C:17]([O:19][CH3:20])=[O:18])([CH3:14])[O:13][C:8]=2[C:7]=1[CH2:23][CH2:24][CH3:25].[CH3:26][CH2:27][CH2:28][C:29]1[C:34]([OH:35])=[C:33]([C:36]([CH3:38])=[O:37])[CH:32]=[CH:31][C:30]=1[OH:39]>>[C:36]([C:33]1[CH:32]=[CH:31][C:30]([O:39][CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:22]=[CH:21][C:9]3[CH2:10][CH2:11][C:12]([CH2:15][CH2:16][C:17]([O:19][CH3:20])=[O:18])([CH3:14])[O:13][C:8]=3[C:7]=2[CH2:23][CH2:24][CH3:25])=[C:29]([CH2:28][CH2:27][CH3:26])[C:34]=1[OH:35])(=[O:37])[CH3:38]Participants
3
Reactant 2
Product 1
Procedure
The title compound mp. 53°-55°, was prepared by the method of Example 6 using the product of Example 11 and 2,4-dihydroxy-3-propylacetophenone as starting materials. Structure assignment was confirmed by nmr and infrared spectra and by elemental analysis.
Sources & evidence
- ORD record
- ord-32404b43281a46879ff0531b66891b90
- Source dataset
- uspto-grants-1987_05
- Patent number
- US04665203
Reaction notes
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