HCID 13393800, compound → HCID 13393825, compound

Participants

Reaction Steps

As in example 14 but starting from 3.16 g 4-chloro-3-formyl-8-methoxy-thioflav-3-ene in 30 ml dry methanol and 0.35 g sodium borohydride. After work up, the crude oil is crystallized in a mixture of n-hexane and ethylacetate. Pure 4-chloro-3-hydroxymethyl-8-methoxy-thioflav-3-ene is obtained as yellow crystals; m.p. 143°-145° C.-TLC (SiO2, n-hexane CH2Cl2 1:1): Rf =0.05.

Provenance & Evidence