HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 4'-Hydroxyacetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Phenol | HCID 996 | — |
| Reactant | Hydrofluoric Acid | HCID 14917 | — |
| Product | 4'-Hydroxyacetophenone | HCID 7469 | 61.6% |
Reaction Steps
Dann and Mylius also disclose the reaction of phenol and glacial acetic acid in the presence of hydrogen fluoride to produce 4-hydroxyacetophenone in a yield of 61.6%. This reaction may be conventionally characterized as a Friedel-Crafts acetylation of phenol with acetic acid as the acetylating agent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04665215 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-fac015831fa8409aa43737829431db16 |
| Source note | uspto-grants-1987_05 |