Toluene → 2-Chloro-1-(4-methylphenyl)ethan-1-one

HRID 978910Notes

Reaction equation

[Cl:1][CH2:2][C:3](Cl)=[O:4].[C:6]1([CH3:12])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[Cl:1][CH2:2][C:3]([C:9]1[CH:10]=[CH:11][C:6]([CH3:12])=[CH:7][CH:8]=1)=[O:4]

Participants

Reactant 2

HCID 1140Toluene

HCID 6577Chloroacetyl chloride

Product 1

HCID 2378052-Chloro-1-(4-methylphenyl)ethan-1-one

Procedure

reacting toluene with chloroacetyl chloride in the presence of a Friedel-Crafts catalyst in a suitable solvent to produce 4-(2-chloroacetyl)toluene,

Sources & evidence

ORD record: ord-a058c95987d5424181cf14de1164b29d
Source dataset: uspto-grants-1987_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04665246

Reaction notes

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