Hydrochloric Acid → HCID 13633544, compound

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Reaction Steps

The product obtained in Example 3 (5 g), acetic acid (20 cc) and anhydrous zinc chloride (320 mg) are introduced, under an argon atmosphere, into a reactor. A solution (5 cc) of hydrochloric acid in acetic acid (1.9 moles of hydrochloric acid per liter) is added. Thereafter, acetic anhydride (2.7 cc) is added over 15 minutes. The temperature rises from 20° to 30° C. After 2 hours' stirring, water (10 cc), sodium acetate (800 mg) and ethyl acetate (100 cc) are added. After evaporation of the solvents, the residue is taken up in methylene chloride. After filtration over silica gel, 2,5,7,8-tetramethyl-2-(4',8',12'-trichloro-4',8',12'-trimethyl-tridecyl)-chroman-6-ol acetate (4.99 g) is obtained.

Provenance & Evidence