HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-(4-methoxy-2-methyl-thien-3-yl)-N-(2-ethoxyethyl)chloroacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-(2-Ethoxyethyl)-4-methoxy-2-methylthiophen-3-amine | HCID 20201091 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(4-methoxy-2-methyl-thien-3-yl)-N-(2-ethoxyethyl)chloroacetamide | HCID 14072812 | — |
Reaction Steps
To a well stirred mixture of 6,05 g (0.03 mol) N-(2-ethoxyethyl)-4-methoxy-2-methyl-thiophene-3-amine, 4.15 g (0.03 mol) of K2CO3, 10 ml of water and 100 ml of CH2Cl2 is added dropwise without cooling the solution of 3.4 g (0.03 mol) of chloroacetyl chloride in 10 ml of CH2Cl2. After the exothermic reaction (27°) has subsided, stirring is continued for a further hour at ambient temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04666502 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-ad23bbdb9c1b42a38e09f7b8748acb60 |
| Source note | uspto-grants-1987_05 |