Ammonia → N-(2,4-Dimethylthiophen-3-yl)-2-hydroxyacetamide

HRID 978926Notes

Reaction equation

HRID 978926 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH3:15])[C:6]=1[NH:7][C:8](=[O:14])[CH2:9][O:10]C(=O)C.N>CO>[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH3:15])[C:6]=1[NH:7][C:8](=[O:14])[CH2:9][OH:10]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 202010872-[(2,4-Dimethylthiophen-3-yl)amino]-2-oxoethyl acetate

Product 1

HCID 20201100N-(2,4-Dimethylthiophen-3-yl)-2-hydroxyacetamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Through a stirred solution of 15.9 g (0.07 mol) of N-(2,4-dimethyl-thien-3yl)-acetoxyacetamide in 300 ml of methanol is bubbled a gentle stream of ammonia gas for 30 minutes.

Sources & evidence

ORD record
ord-94ec56f45dc149eca6d8118af159abdb
Source dataset
uspto-grants-1987_05
Patent number
US04666502

Reaction notes

Loading…