Dimethyl Sulfate → HCID 54170383, compound

Participants

Reaction Steps

To a mixture of 9.5 g (0.037 mol) N-(2,4-dimethyl-thien-3-yl)-N-(4-methyl-5-mercapto-1,2,4-triazol-3-yl-methyl)-amine, 1.1 g triethyl-benzyl ammonium chloride in 100 ml toluene and 30 ml aqueous 50% sodium hydroxide solution are added 4.7 g (0.037 mol) dimethylsulfate. The reaction mixture is stirred at room temperature for 5 hours, the organic layer is separated, washed with three 100 ml portions of water, dried over Na2SO4 and evaporated to dryness. The residue is recrystallized twice from ether giving the pure title compound, m.p. 92°-96° C.

Provenance & Evidence