Potassium Hydroxide → HCID 13882135, compound

HRID 978947Notes

Reaction equation

HRID 978947 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[C:13]([C:14]#[N:15])=[C:12]([C:16]([O:18]CC)=[O:17])[CH:11]=[N:10]1.[OH-:21].[K+]>C(O)C>[C:16]([C:12]1[CH:11]=[N:10][N:9]([C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([Cl:8])[C:2]=2[Cl:1])[C:13]=1[C:14]([NH2:15])=[O:21])([OH:18])=[O:17]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 13772965HCID 13772965, compound

Product 1

HCID 13882135HCID 13882135, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 15 g. portion of ethyl 1-(2,3-dichlorophenyl)-5-cyano-4-pyrazolecarboxylate was stirred under reflux overnight in 200 ml. of ethanol with 6 g. of potassium hydroxide. The reaction mixture was chromatographed over silica gel, and the product-containing fractions were combined and evaporated to dryness. The residues were recrystallized from ethanol-water to obtain 1.31 g. of the desired product, m.p. 228°-230°, which was identified by elemental analysis.

Workup

  1. temperatureunder reflux overnight in 200 ml
  2. customThe reaction mixture was chromatographed over silica gel
  3. customevaporated to dryness
  4. customThe residues were recrystallized from ethanol-water
  5. customto obtain 1.31 g

Sources & evidence

ORD record
ord-434aedd83e894c96b64a3f4296198299
Source dataset
uspto-grants-1987_05
Patent number
US04666504

Reaction notes

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