HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → Benzyl 2-methylaziridine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | 2-Methylaziridine | HCID 6377 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Benzyl 2-methylaziridine-1-carboxylate | HCID 21895246 | — |
Reaction Steps
2-Methyl aziridine is dissolved in CH2Cl2 and triethylamine under argon at 0° C. Benzylchloroformate is added and the contents of the flask are at room temperature overnight. The mixture is poured into 10% citric acid and is extracted with CHCl3. The organic layer is washed with dilute aqueous NaHCO3 and dried over MgSO4. The solution is evaporated to yield N-Cbz-2-methyl aziridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04666729 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-765bacff03074573989da6ae22f6ff52 |
| Source note | uspto-grants-1987_05 |