Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Boron trifluoride etherate → N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Boron trifluoride etherate | HCID 8000 | — |
| 반응물 | 2,2,4,4-Tetramethylpentan-3-ol | HCID 139790 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Benzyl 2-methylaziridine-1-carboxylate | HCID 21895246 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane | HCID 20201216 | — |
반응 단계
N-Cbz-2-Methyl aziridine and di-t-butylmethanol are dissolved in CH2Cl2 at 0° C. under argon. Boron trifluoride etherate is added and the flask is stirred overnight. The contents are poured into saturated NaHCO3 and are extracted with ethyl acetate. The organic layer is dried over MgSO4 and evaporated to yield N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04666729 |
| 출처 데이터셋 | uspto-grants-1987_05 |
| ORD ID | ord-ac71cc7775c045aa8166b0c6f8206357 |
| 출처 메모 | uspto-grants-1987_05 |