Sodium Carbonate → HCID 70442278, compound

HRID 979022Notes

Reaction equation

HRID 979022 reaction equation
[NH2:1][C@@H:2]1[C:14](=[O:15])[N:4]2[CH:5]([C:11]([OH:13])=[O:12])[C@:6]([CH:9]=[CH2:10])([CH3:8])[S:7][C@H:3]12.[O:16]([CH2:23][C:24](Cl)=[O:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(=O)([O-])[O-].[Na+].[Na+]>CC(C)=O.O>[O:16]([CH2:23][C:24]([NH:1][C@@H:2]1[C:14](=[O:15])[N:4]2[CH:5]([C:11]([OH:13])=[O:12])[C@:6]([CH:9]=[CH2:10])([CH3:8])[S:7][C@H:3]12)=[O:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 69703Phenoxyacetyl chlorideHCID 67900383HCID 67900383, compound

Product 1

HCID 70442278HCID 70442278, compound

Reagents, catalysts & solvents 1

HCID 18366337Propan-2-one--water (1/1)Solvent

Procedure

6β-Amino-2α-vinyl-2β-methylpenam-3-carboxylic acid is acylated in acetone-water with phenoxyacetyl chloride in the presence of sodium carbonate to provide the title compound.

Sources & evidence

ORD record
ord-41635698e0b24c9d93696b4914cc31fc
Source dataset
uspto-grants-1987_05
Patent number
US04666835

Reaction notes

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