反应详情

2-Bromopropionyl bromide (10.6 g) is added dropwise to a stirring mixture of 3,4-dihydro-2(1H)-quinazolinone (3.2 g) and anhydrous aluminum chloride (7.9 g) in carbon disulfide (60 ml). The reaction mixture is refluxed for four hours, the carbon disulfide decanted and the residue treated with aqueous hydrochloric acid (6N). The acidic residue is poured into ice water, and the precipitate filtered, washed with water and dried, affording the desired product as a solid, which is used in the next step without further purification.

1. temperatureThe reaction mixture is refluxed for four hours
2. customthe carbon disulfide decanted
3. additionthe residue treated with aqueous hydrochloric acid (6N)
4. additionThe acidic residue is poured into ice water
5. filtrationthe precipitate filtered
6. washwashed with water
7. customdried