HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Dithionite → 4-chloro-3-hydroxy-10H-phenothiazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Dithionite | HCID 24489 | — |
| Reactant | 3H-Phenothiazin-3-one, 4-chloro- | HCID 11776748 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-chloro-3-hydroxy-10H-phenothiazine | HCID 9881418 | 95% |
Reaction Steps
A solution of Na2S2O4 (70 g) in water (500 ml) was added to a solution of 4-chloro-3H-phenothiazin-3-one (50 g) in DMF (1200 ml). The reaction mixture was stirred at room temperature for 3 hours and then poured in 5 liters of water. The resulting precipitate was then filtered to give the 4-chloro-3-hydroxy-10H-phenothiazine (95%). m.p.: 110° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04666907 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-59864131e5c34b0582e817f322c40d52 |
| Source note | uspto-grants-1987_05 |