反应详情

Add 8-benzylaminotheophylline (30 g.) and ethyl malonyl chloride (35.1 gm) to 600 ml of 1:1 dioxane/acetonitrile. Heat the reaction mixture to reflux under a nitrogen atmosphere until the 8-benzylaminotheophylline is consumed (Ca. 3.5 hrs.). Cool the reaction mixture to room temperature and pour the solution into 800 ml. of ether. Filter the precipitate. Wash the precipitate with ether and dry the product to obtain the title compound, m.p. 205.5°-209° C.

1. temperatureHeat the reaction mixture
2. customis consumed (Ca. 3.5 hrs.)
3. additionpour the solution into 800 ml
4. filtrationFilter the precipitate
5. washWash the precipitate with ether
6. customdry the product