3,6-Bis[2-(diethylamino)ethoxy]-4,5-acridinedimethanol → 3,6-Bis[2-(diethylamino)ethoxy]-4,5-diformylacridine

HRID 979106Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 979106
[CH2:1]([N:3]([CH2:33][CH3:34])[CH2:4][CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]2[C:19]([C:20]=1[CH2:21][OH:22])=[N:18][C:17]1[C:16]([CH2:23][OH:24])=[C:15]([O:25][CH2:26][CH2:27][N:28]([CH2:31][CH3:32])[CH2:29][CH3:30])[CH:14]=[CH:13][C:12]=1[CH:11]=2)[CH3:2]>CS(C)=O.C(N(CC)CC)C>[CH2:31]([N:28]([CH2:29][CH3:30])[CH2:27][CH2:26][O:25][C:15]1[CH:14]=[CH:13][C:12]2[C:17]([C:16]=1[CH:23]=[O:24])=[N:18][C:19]1[C:10](=[CH:9][CH:8]=[C:7]([O:6][CH2:5][CH2:4][N:3]([CH2:33][CH3:34])[CH2:1][CH3:2])[C:20]=1[CH:21]=[O:22])[CH:11]=2)[CH3:32]

Komponenten

4

Edukt 1

HCID 201846723,6-Bis[2-(diethylamino)ethoxy]-4,5-acridinedimethanol

Produkt 1

HCID 202016653,6-Bis[2-(diethylamino)ethoxy]-4,5-diformylacridineAusbeute 75,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittel2×HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

To a solution of 0.469 g of 3,6-bis[2-(diethylamino)ethoxy]-4,5-acridinedimethanol in a mixture of 5.0 ml of anhydrous dimethyl sulfoxide and 2.8 ml of triethylamine is added a solution of 0.96 g of sulfur trioxide-pyridine complex in 5 ml of anhydrous dimethyl sulfoxide. The reaction mixture is stirred at room temperature for one hour. Most of the dimethyl sulfoxide is removed under reduced pressure without heat. The residue is treated first with 50 ml of saturated sodium bicarbonate solution and then with 50 ml of water, giving 0.35 g of the desired product as a yellow solid.

Aufarbeitung

  1. customMost of the dimethyl sulfoxide is removed under reduced pressure
  2. temperaturewithout heat
  3. additionThe residue is treated first with 50 ml of saturated sodium bicarbonate solution

Quellen und Nachweise

ORD-Eintrag
ord-8f0c4ed1ce7f48d0914e1345f46eaadc
Quelldatensatz
uspto-grants-1987_05
Patentnummer
US04666917

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