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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 979107Generated: October 31, 2026

2-Methoxyaniline → HCID 13562774, compound

https://huagongshe.com/reaction/979107

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-MethoxyanilineHCID 7000—
ReactantEthyl 4-hydroxy-2-(methylsulfanyl)-5-pyrimidinecarboxylateHCID 239049—
SolventDimethylformamideHCID 6228—
ProductHCID 13562774HCID 1356277474.1%

Reaction Steps

Ethyl 1,6-dihydro-2-methylthio-6-oxo-5-pyrimidinecarboxylate (5 g) and 2-methoxyaniline (3.4 g) are added to DMF (20 ml), and the mixture is refluxed with stirring for 8 hours. After cooling, the precipitate is collected by filtration and recrystallized from DMF to give ethyl 1,6-dihydro-2-(2-methoxyanilino)-6-oxo-5-pyrimidinecarboxylate (5 g). M.p. 217°-219° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04666915
Source datasetuspto-grants-1987_05
ORD IDord-d6a24909e8c646ac8a94b06f2b0d78f4
Source noteuspto-grants-1987_05