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HRID979110

反应详情

EQUATION

反应方程式

HRID 979110 的结构方程式

REACTANTS

反应物

2
结构：CC(C)Oc1ccccc1N
HCID34436

2-Isopropoxyaniline

C9H13NO

结构：CCOC(=O)c1cnc(SC)[nH]c1=O
HCID239049

Ethyl 2-(methylsulfanyl)-6-oxo-1,6-dihydropyrimidine-5-carboxylate

C8H10N2O3S

PRODUCTS

生成物

1
结构：CCOC(=O)c1cnc(Nc2ccccc2OC(C)C)[nH]c1=O
HCID13562778

未命名化合物

收率 38.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Ethyl 1,6-dihydro-2-methylthio-6-oxo-5-pyrimidinecarboxylate (15 g) and 2-(1-methylethoxy)aniline (11.5 g) are added to ethanol (100 ml), and the mixture is refluxed with stirring for 17 hours. After cooling, the precipitate is collected by filtration and recrystallized from DMF to give ethyl 1,6-dihydro-2-[2-(1-methylethoxy)anilino]-6-oxo-5-pyrimidinecarboxylate (8.5 g). M.p. 205°-207° C.

WORKUP

后处理

  1. temperaturethe mixture is refluxed
  2. temperatureAfter cooling
  3. filtrationthe precipitate is collected by filtration
  4. customrecrystallized from DMF