HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dimethylaniline → HCID 13562807, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dimethylaniline | HCID 7259 | — |
| Reactant | Ethyl 4-hydroxy-2-(methylsulfanyl)-5-pyrimidinecarboxylate | HCID 239049 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 13562807 | HCID 13562807 | 45.5% |
Reaction Steps
Ethyl 1,6-dihydro-2-methylthio-6-oxo-5pyrimidinecarboxylate (10 g) and 2,5-dimethylaniline (8.5 g) are added to ethanol (150 ml), and the mixture is refluxed with stirring for 17 hours. After cooling, the precipitate is collected by filtration and recrystallized from DMF to give ethyl 1,6-dihydro-6-oxo-2-(2,5-dimethylanilino)-5-pyrimidinecarboxylate (6.1 g). M.p. 252°-254° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04666915 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-3e89fd9da71740d580eb0151b5ba5b75 |
| Source note | uspto-grants-1987_05 |