反应详情

Ethyl 1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylate (12 g) and sodium hydroxide (3 g) are added to water (150 ml), and the mixture is refluxed with stirring for 1 hour. After cooling, the reaction mixture is acidified with acetic acid, and the resulting solid is collected by filtration and recrystallized from DMF. The precipitate thus obtained is collected by filtration and added to water (100 ml), and the mixture is refluxed with stirring for 1 hour. After cooling, the resulting product is collected by filtration and dried at 80° C. under reduced pressure to give 1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylic acid (8 g). M.p. 212°-214° C.

1. temperaturethe mixture is refluxed
2. temperatureAfter cooling
3. filtrationthe resulting solid is collected by filtration
4. customrecrystallized from DMF
5. customThe precipitate thus obtained
6. filtrationis collected by filtration
7. additionadded to water (100 ml)
8. temperaturethe mixture is refluxed
9. stirringwith stirring for 1 hour
10. temperatureAfter cooling
11. filtrationthe resulting product is collected by filtration
12. customdried at 80° C. under reduced pressure