反应详情

Ethyl 1,6-dihydro-2-(2-fluoroanilino)-6-oxo-5-pyrimidinecarboxylate (5 g) and sodium hydroxide (2 g) are added to water (100 ml), and the mixture is refluxed with stirring for 1 hour. After cooling, the reaction mixture is acidified with acetic aicd, and the resulting solid is collected by filtration and recrystallized from DMF. The precipitate is collected by filtration and added to water (70 ml), and the mixture is refluxed with stirring for 1 hour. After cooling, the resulting product is collected by filtration and dried at 80° C. under reduced pressure to give 1,6-dihydro-2-(2-fluoroanilino)-6-oxo-5-pyrimidinecarboxylic acid (3.1 g). M.p. 300° C.

1. temperaturethe mixture is refluxed
2. temperatureAfter cooling
3. filtrationthe resulting solid is collected by filtration
4. customrecrystallized from DMF
5. filtrationThe precipitate is collected by filtration
6. additionadded to water (70 ml)
7. temperaturethe mixture is refluxed
8. stirringwith stirring for 1 hour
9. temperatureAfter cooling
10. filtrationthe resulting product is collected by filtration
11. customdried at 80° C. under reduced pressure