HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 979136Generated: October 29, 2026
Aniline → Ethyl 2-anilino-1,6-dihydro-6-oxo-5-pyrimidinecarboxylate
https://huagongshe.com/reaction/979136
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Ethyl 4-hydroxy-2-(methylsulfanyl)-5-pyrimidinecarboxylate | HCID 239049 | — |
| Product | Ethyl 2-anilino-1,6-dihydro-6-oxo-5-pyrimidinecarboxylate | HCID 13913527 | 61.2% |
Reaction Steps
A mixture of ethyl 1,6-dihydro-2-methylthio-6-oxo-5-pyrimidinecarboxylate (5 g) and aniline (2.6 g) is heated without solvent at 130° C. for 1 hour. After cooling, the resulting solid is pulverized and recrystallized from DMSO to give ethyl 2-anilino-1,6-dihydro-6-oxo-5-pyrimidinecarboxylate (3.7 g). M.p. 267°-269° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04666915 |
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| Source dataset | uspto-grants-1987_05 |
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| ORD ID | ord-423ed751c0014bc68a7e97ed611f9e6c |
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| Source note | uspto-grants-1987_05 |
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