Sodium Carbonate → Sodium 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate

HRID 979138Notes

Reaction equation

HRID 979138 reaction equation
[CH3:1][CH:2]([CH3:22])[CH2:3][O:4][C:5]1[CH:21]=[CH:20][CH:19]=[CH:18][C:6]=1[NH:7][C:8]1[NH:9][C:10](=[O:17])[C:11]([C:14]([OH:16])=[O:15])=[CH:12][N:13]=1.C(=O)([O-])[O-].[Na+:27].[Na+]>C(O)C.O>[CH3:1][CH:2]([CH3:22])[CH2:3][O:4][C:5]1[CH:21]=[CH:20][CH:19]=[CH:18][C:6]=1[NH:7][C:8]1[NH:9][C:10](=[O:17])[C:11]([C:14]([O-:16])=[O:15])=[CH:12][N:13]=1.[Na+:27]

Participants

5

Reactant 2

HCID 10340Sodium CarbonateHCID 9817898Mar 99

Product 1

HCID 23692303Sodium 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylateYield 57.8%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylic acid (20 g) and sodium carbonate (7.0 g) in ethanol (100 ml) and water (100 ml) is heated until the solution is completed. After allowing to stand the solution overnight, the precipitate is collected by filtration, washed with water and dried to give sodium 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate (12.4 g). M.p. 231°-233° C.

Workup

  1. temperatureis heated until the solution
  2. customthe solution overnight
  3. filtrationthe precipitate is collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-245f2c7448ab4c7e88f50af9908cd9d3
Source dataset
uspto-grants-1987_05
Patent number
US04666915

Reaction notes

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