Formaldehyde → HCID 13851321, compound

Participants

Reaction Steps

A solution of 1.65 g (±)-[4R*,4aS*,10bR*]-7-bromo-4-(hydroxymethyl)-1,3,4,4a,5,10b-hexahydro-9-methoxy-2H-[1]benzopyrano[4,3-c]pyridine in 0.5 ml 37% HCHO and 2.2 ml HCO2H is heated at 100° for 20 min. The reaction mixture is concentrated in vacuo and partitioned between 10 ml 2N NaOH and 50 ml CH2Cl2. The organic phase is dried over Na2SO4, filtered and concentrated under reduced pressure to yield the title compound; m.p. of HCl salt 262° dec.

Provenance & Evidence