Triethylamine → HCID 53720630, compound

Participants

Reaction Steps

To a solution of 1.69 g of (±)-[4R*,4aS*,10bR*]-7-bromo-4-(hydroxymethyl)-1,3,4,4a,5,10b-hexahydro-9-methoxy-2-methyl-2 H-[1]benzopyrano[4,3-c]pyridine and 0.82 ml triethylamine in 60 ml CH2Cl2 is added 0.42 ml of methanesulfonyl chloride. After 15 min. 1 drop methanol is added and the reaction mixture is washed with saturated NaHCO3 and dried over Na2SO4. Filtration and removal of solvents under reduced pressure yields (±)-[4R*,4aS*,10bR*]-7-bromo-4-(methylsulfonyloxymethyl)-1,3,4,4a,5,10b-hexahydro-9-methoxy-2-methyl-2H-[1]benzopyrano[4,3-c]pyridine.

Provenance & Evidence