HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Iodopropane → HCID 13851345, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Iodopropane | HCID 33643 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 13851343 | HCID 13851343 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 13851345 | HCID 13851345 | — |
Reaction Steps
A solution of 0.235 g (±)-[4aR*,10bS*]-1,3,4,4a,5,10b-hexahydro-2H-[1]benzopyrano[4,3-c]pyridine in 5 ml toluene is refluxed with 200 mg iodopropane and 3 ml saturated NaHCO3 solution for 2 hours. The organic phase is separated, dried over Na2SO4, filtered, concentrated in vacuo, and flash chromatographed with CH2Cl2 /ammonia saturated methanol (95:5)to give the title compound; m.p. HCl salt 245°-247°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04666916 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-bce7911e51eb4a8c984214c1f7f9f937 |
| Source note | uspto-grants-1987_05 |