3-Chloropropionic acid → HCID 13851425, compound

Participants

Reaction Steps

A mixture of 16.1 g 4-methoxy-2-methylbenzenethiol, 20 g 3-chloropropionic acid and 31.5 g CsF in 200 ml CH3CN is refluxed 40 hours. The cooled reaction mixture is poured into 200 ml 1N NaOH, and washed with 500 ml ether. The aqueous phase is acidified with 12N HCl and extracted with three 100 ml portions of CH2Cl2. The combined extracts are washed to 100 ml brine, dried over Na2SO4, filtered and evaporated to dryness in vacuo to afford 3-[(2-methyl-4-methoxyphenyl)thio]propanoic acid.

Provenance & Evidence