Chlorosulfonic acid → HCID 20201777, compound

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Reaction Steps

There was reacted 1.0 g (5.8 mmole) of 2-acetyl-7-methylbenzofuran with chlorosulfonic acid as in Example 1, yielding 0.36 g of 2-acetyl-4-chlorosulfonyl-7-methylbenzofuran (yield: 24%, MS (m/z): 232 (M+), 257, 237 and 173). The obtained chlorosulfonyl compound was reacted with glycine ethyl ester hydrochloride as in Example 1 to give an ester compound (yield: 73%, MS (m/z): 339 (M+), 266, 237 and 173), which was then hydrolyzed to give 2-acetyl-4-(N-carboxymethylsulfamoyl)-7-methylbenzofuran (yellow plates, yield: 71%). The physical constants are shown in Table 4.

Provenance & Evidence