Chlorosulfonic acid → HCID 20201772, compound

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Reaction Steps

There was reacted 0.95 g (5 mmole) of 2-acetyl-4-methoxybenzofuran with chlorosulfonic acid as in Example 1, yielding 1.3 g of 2-acetyl-4-methoxy-7-chlorosulfonylbenzofuran (yield: 93%, MS (m/z): 288 (M+), 273, 253 and 189). The obtained chlorosulfonyl compound was reacted with glycine ethyl ester hydrochloride to give an ester compound (yield: 97%, MS (m/z): 354 (M+), 281, 252 and 188), which was then hydrolyzed to give 2-acetyl-4-methoxy-7-(N-carboxymethylsulfamoyl)benzofuran (yellow plates, yield: 84%). The physical constants are shown in Table 4.

Provenance & Evidence