Potassium Nitrate → HCID 13589252, compound

HRID 979210Notes

Reaction equation

HRID 979210 reaction equation
[C:1]([NH:9][C:10]1[CH:18]=[C:17]2[C:13]([CH2:14][C:15](=[O:19])[NH:16]2)=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[N+:20]([O-])([O-:22])=[O:21].[K+]>S(=O)(=O)(O)O>[C:1]([NH:9][C:10]1[CH:18]=[C:17]2[C:13]([CH2:14][C:15](=[O:19])[NH:16]2)=[CH:12][C:11]=1[N+:20]([O-:22])=[O:21])(=[O:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 13589253HCID 13589253, compound

Product 1

HCID 13589252HCID 13589252, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent2×

Procedure

5.5 g. (21.7 mMol) 6-isonicotinoylaminoindolin-2-one are dissolved portionwise in 20 ml. concentrated sulphuric acid, cooled with ice and 2.19 g. (21.7 mMol) potassium nitrate dissolved in concentrated sulphuric acid slowly added dropwise thereto. After 2 hours, the solution is poured on to ice, neutralised and filtered with suction. The residue is substantially dissolved in 2N hydrochloric acid, filtered, treated with Floridin (fullers' earth), filtered with suction and neutralised. There are obtained 4.5 g. (70% of theory) of the title compound; m.p. >300° C.

Workup

  1. additionslowly added dropwise
  2. additionthe solution is poured on to ice
  3. filtrationneutralised and filtered with suction
  4. dissolutionThe residue is substantially dissolved in 2N hydrochloric acid
  5. filtrationfiltered
  6. additiontreated with Floridin (fullers' earth),
  7. filtrationfiltered with suction
  8. customThere are obtained 4.5 g

Sources & evidence

ORD record
ord-a496221a43e940cfb70beac571161e8f
Source dataset
uspto-grants-1987_05
Patent number
US04666923

Reaction notes

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