HCID 13671488, compound → HCID 22162210, compound

HRID 979213Notes

Reaction equation

HRID 979213 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([CH3:28])[C:14]2[C:9](=[CH:10][C:11]([NH:18][C:19]([C:21]3[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=3)=[O:20])=[C:12]([N+:15]([O-])=O)[CH:13]=2)[NH:8][C:7]1=[O:27])=[O:5])[CH3:2]>[Pd].CO>[NH2:15][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][C:11]=1[NH:18][C:19]([C:21]1[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=1)=[O:20])[NH:8][C:7](=[O:27])[C:6]2([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH3:28]

Participants

4

Reactant 1

HCID 13671488HCID 13671488, compound

Product 1

HCID 22162210HCID 22162210, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 12.4 g. (32.2 mmol) 3-ethoxycarbonyl-3-methyl-5-nitro-6-(4-pyridinoylamino)-indolin-2-one in 500 ml. methanol is hydrogenated at ambient temperature in the presence of 1 g. 10% Pd/C. The catalyst is filtered off with suction, the filtrate is evaporated and the substance obtained is immediately further worked up.

Workup

  1. customis hydrogenated at ambient temperature in the presence of 1 g
  2. filtrationThe catalyst is filtered off with suction
  3. customthe filtrate is evaporated
  4. customthe substance obtained

Sources & evidence

ORD record
ord-7ecb45e03408405c80b80811beb6fdb9
Source dataset
uspto-grants-1987_05
Patent number
US04666923

Reaction notes

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