HCID 21621270, compound → HCID 87126116, compound

HRID 979263Notes

Reaction equation

HRID 979263 reaction equation
C[O:2][C:3](=[O:22])[CH2:4][CH2:5][O:6][N:7]([CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C[Si](C)(C)[O-].[K+:28]>C1(C)C=CC=CC=1>[K+:28].[CH2:15]([N:7]([CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[O:6][CH2:5][CH2:4][C:3]([O-:22])=[O:2])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 21621270HCID 21621270, compoundHCID 23668039Potassium trimethylsilanolate

Product 1

HCID 87126116HCID 87126116, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a stirred solution of 9.75 g of the compound of Example I in 100 ml of toluene is added 3.85 g of potassium trimethylsilanolate. After stirring the mixture at room temperature for 12 hours, the mixture is concentrated under reduced pressure and the residue is triturated with ether to leave the title compound as an off-white hygroscopic solid.

Workup

  1. concentrationthe mixture is concentrated under reduced pressure
  2. customthe residue is triturated with ether

Sources & evidence

ORD record
ord-e09a25c6a02a4ae192969210919bf411
Source dataset
uspto-grants-1987_05
Patent number
US04666962

Reaction notes

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