HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 20202114, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 4-Bromothiophene-2-carbaldehyde | HCID 87792 | — |
| Reactant | 4-(1H-Imidazol-1-yl)thiophene-2-carbaldehyde | HCID 13318712 | — |
| Reactant | HCID 20202129 | HCID 20202129 | — |
| Product | HCID 20202114 | HCID 20202114 | — |
Reaction Steps
4-Bromo-thiophen-2-aldehyde is reacted with imidazol to 4-(imidazol-1-yl)-thiophen-2-aldehyde which is reacted with the necessary acid nitrile to 4-[4-(imidazol-1-yl)-thien-2-yl]-4-oxo-butyric acid nitrile which is hydrolized to 4-[4-(imidazol-1-yl)-thien-2-yl]-4-oxo-butyric acid. This compound is reacted with hydrazine hydrate to yield 4.5-dihydro-6-[4-(imidazol-1-yl)-thien-2-yl]-3-(2H)-pyridazinone which is subsequently dehydrogenated with 3-nitrobenzolsulfonic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04667033 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-8cbeea1a54574b039fce5a1f0c62037f |
| Source note | uspto-grants-1987_05 |