Methyl iodide → HCID 13853737, compound

Participants

Reaction Steps

Potassium tert.-butoxide (500 mg) was added to a suspension of 1-hydroxy-6-methyl-5H-benzo[a]phenothiazin-5-one (from Example 32) (500 mg) and methyl iodide (2 ml) in DMF (20 ml). After 30 minutes at room temperature, EtOAc (250 ml) was added followed by water (200 ml). The aqueous layer was decanted and the organic layer was dried and evaporated to dryness. The residue was treated with ether, filtered and air-dried to afford the desired product (420 mg), m.p. 170°-171° C.

Provenance & Evidence