HCID 13842071, compound → HCID 178515739, compound

HRID 979302Notes

Reaction equation

HRID 979302 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:6][C:7]3[C:12]([S:13](=[O:17])(=[O:16])[C:14]=2[CH:15]=1)=[CH:11][CH:10]=[CH:9][CH:8]=3.Cl([O-])=[O:19].[Na+]>S(=O)(=O)(O)O.O>[OH:19][C:15]1[C:2](=[O:1])[CH:3]=[CH:4][C:5]2[C:14]=1[S:13](=[O:17])(=[O:16])[C:12]1[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[N:6]=2

Participants

5

Reactant 2

HCID 13842071HCID 13842071, compoundHCID 23668197Sodium Chlorite

Product 1

HCID 178515739HCID 178515739, compoundYield 94.6%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1118Sulfuric AcidSolvent

Procedure

To a suspension of 3-hydroxy-10H-phenothiazine-5,5-dioxide (1.75 g, 7 mmoles) in 2% aqueous sulfuric acid (25 ml) there was added, at room temperature, a solution of 80% sodium chlorite (3.17 g, 28 mmoles) in water (25 ml). The mixture was stirred for 15 minutes, then the red-orange precipitate was filtered to afford crude product (1.73 g). Purification was achieved by crystallization from DMF-methanol, m.p. 266° (dec.).

Workup

  1. additionwas added, at room temperature
  2. filtrationthe red-orange precipitate was filtered

Sources & evidence

ORD record
ord-193a5ffd0bcb46788505eb6663dc31f9
Source dataset
uspto-grants-1987_05
Patent number
US04667032

Reaction notes

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