2-Aminothiophenol → HCID 13723586, compound

HRID 979304Notes

Reaction equation

HRID 979304 reaction equation
[C:1]([C:5]1[C:6](=[O:16])[C:7](=O)[CH:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[NH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[SH:24]>CCOCC>[C:1]([C:5]1[C:6](=[O:16])[C:7]2[C:8](=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=1)[S:24][C:19]1[C:18](=[CH:23][CH:22]=[CH:21][CH:20]=1)[N:17]=2)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 87132-AminothiophenolHCID 769153,5-Di-tert-butyl-1,2-benzoquinone

Product 1

HCID 13723586HCID 13723586, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of 4.4 gm of 3,5-di-t-butyl-1,2-benzoquinone in 20 ml of ether was added a solution of 1.25 g of 2-aminothiophenol in 5 ml of ether. After stirring for 1 hour at 25°, the reaction mixture was evaporated. The residue was purified by flash chromatography on silica gel using 2% ethyl acetate in benzene as eluent. There was thus obtained 860 mg of the title compound as dark blue plates, m.p. 137°-141°.

Workup

  1. customthe reaction mixture was evaporated
  2. customThe residue was purified by flash chromatography on silica gel using 2% ethyl acetate in benzene as eluent

Sources & evidence

ORD record
ord-04f18155cf2e4771bb34c17a9ecb516a
Source dataset
uspto-grants-1987_05
Patent number
US04667032

Reaction notes

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