Methanol → HCID 13853732, compound

Participants

Reaction Steps

To a suspension of 1,7-dimethoxy-3H-phenothiazin-3-one (800 mg) in acetic acid (24 ml) was added a 1.15M solution of Cl2 in acetic acid (3.1 ml). After 15 minutes, methanol was added and the mixture was filtered, washed with ether and air dried to afford a mixture of the two title compounds (700 mg), which were separated on a silica gel column (EtOAc:CH2Cl2, 1:9), affording 4-chloro-1,7-dimethoxy-3H-phenothiazin-3-one, m.p. 278°-280° C. (dec.)

Provenance & Evidence