Saccharin → HCID 20201759, compound

Participants

Reaction Steps

36,6 g (0.2 mol) of 3-keto-2H,3H-1,2-benzisothiazole 1,1-dioxide and 70 g (1,4 mol) of hydrazine hydrate in 250 ml of n-butanol are boiled under reflux for about 25 hours. Further 250 ml n-butanol are added and the solution is then evaporated down in vacuo, and the hemicrystalline residue is stirred with 50 ml of glacial acetic acid. The crystal slurry is filtered under suction. 37,2 g (94% of theory) of 3-hydrazino-2H,3H-1,2-benzisothiazole 1,1-dioxide of melting point 262° C. are obtained.

Provenance & Evidence