HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 11-[1-(2,4,6-Trimethylbenzyl)piperidin-4-yl]-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,4,6-Trimethylbenzyl chloride | HCID 74108 | — |
| Reactant | 11-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine | HCID 13689358 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 11-[1-(2,4,6-Trimethylbenzyl)piperidin-4-yl]-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine | HCID 13689365 | — |
Reaction Steps
To 60 ml DMF, was added 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (5.0 g, 0.0186 mole), 2,4,6-trimethylbenzyl chloride (4.2 g, 0.025 mole), milled K2CO3 (15 g, 0.1 mole) and KI (0.01 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04667039 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-d91af6f08ca746c88b3c4e3bef6dcec9 |
| Source note | uspto-grants-1987_05 |