反应详情

A mixture of 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (5.1 g, 0.019 mole), 4-hydroxy-3-methoxyphenethyl chloride (4.25 g, 0.023 mole) and NaHCO3 (11 g) in 110 ml n-butyl acetate was heated at reflux for 18 hours. The reaction mixture was then cooled, filtered and concentrated to an oil.

1. temperaturewas heated
2. temperatureat reflux for 18 hours
3. temperatureThe reaction mixture was then cooled
4. filtrationfiltered
5. concentrationconcentrated to an oil