HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 979346Generated: October 25, 2026
Potassium Carbonate → 11-{1-[2-(4-Trifluoromethylphenyl)ethyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine
https://huagongshe.com/reaction/979346
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 11-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine | HCID 13689358 | — |
| Reactant | 4-Trifluoromethylphenethyl methanesulfonate | HCID 54310915 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 11-{1-[2-(4-Trifluoromethylphenyl)ethyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine | HCID 13689409 | — |
Reaction Steps
A mixture of 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (5.07 g, 0.019 mole), (p-trifluoromethylphenyl)ethyl methanesulfonate (6.08 g, 0.023 mole) and K2CO3 (10.7 g) in 150 ml dimethylformamide was heated at 90° C. for 7 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04667039 |
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| Source dataset | uspto-grants-1987_05 |
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| ORD ID | ord-5243cb1686704e25a5f13be3c4f6556a |
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| Source note | uspto-grants-1987_05 |
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