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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 979364Generated: November 1, 2026

1,2,3,4-Tetrahydroisoquinoline → 3-carboethoxy-6,7-dimethoxy-N-methyl-1,2,3,4-tetrahydroisoquinoline

https://huagongshe.com/reaction/979364

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2,3,4-TetrahydroisoquinolineHCID 7046—
Reactant3-carboxy-6,7-dimethoxy-N-methyl-1,2,3,4-tetrahydroisoquinolineHCID 20202227—
Product3-carboethoxy-6,7-dimethoxy-N-methyl-1,2,3,4-tetrahydroisoquinolineHCID 20202216—

Reaction Steps

The resulting tetrahydroisoquinoline derivative of formula 30 is then esterified with a suitable lower alkanol by standard means to produce a tetrahydroisoquinoline ester of formula 31 (step 2). For example, 3-carboxy-6,7-dimethoxy-N-methyl-1,2,3,4-tetrahydroisoquinoline (30) is treated with HCl in EtOH to produce 3-carboethoxy-6,7-dimethoxy-N-methyl-1,2,3,4-tetrahydroisoquinoline (31).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04667038
Source datasetuspto-grants-1987_05
ORD IDord-ec376af3626944ed8b3b7813ac35f1bc
Source noteuspto-grants-1987_05