Hydrochloric Acid → 3-carboxy-3-[4-(3,4-dimethoxyphenyl)-4-isopropyl-4-cyanobutyl]-6,7-dimethoxy-N-methyl-1,2,3,4-tetrahydroisoquinolinium chloride

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Reaction Steps

The resulting alkylated ester of formula 32 is then hydrolyzed by warming it in 6N HCl to produce a carboxylic acid/ammonium salt of formula 33 (step 4). For example, 3-carboethoxy-3-[4-(3,4-dimethoxyphenyl)-4-isopropyl-4-cyanobutyl]-6,7-dimethoxy-N-methyl-1,2,3,4-tetrahydroisoquinoline (32) is heated at 35° C. in 6N HCl to produce 3-carboxy-3-[4-(3,4-dimethoxyphenyl)-4-isopropyl-4-cyanobutyl]-6,7-dimethoxy-N-methyl-1,2,3,4-tetrahydroisoquinolinium chloride (33).

Provenance & Evidence